Research - Oliver Grundmann, PhD

My main research interests focus on the discovery of natural products for the treatment of a variety of diseases. Either the natural product itself can be utilized as a new treatment modality or it can serve as a precursor for the development of new medications. During my doctoral studies I have spent much time exploring the structure of an anxiolytic and its potential mechanism present in the leaves of the plant Apocynum venetum or "Venetian dogbane".

During my time as a postdoctoral associate at the University of Arizona in 2008 I was able to gain some insight into the mechanisms involved in radiation-induced salivary gland damage. Radiation therapy is commonly used to treat patients with head and neck cancer and as a side effect cause functional and structural changes in salivary glands which significantly impacts the quality of life for patients.

Many significant clinical studies have been conducted in collaboration with Dr. Saunjoo Yoon from the College of Nursing at the University of Florida over the past decade. We have been working together on integrative treatment approaches for gastrointestinal disorders including herbal and dietary supplements for Irritable Bowel Syndrome (IBS) and the utilization of acupuncture to mitigate development and progression of cancer cachexia in patients with gastrointestinal malignancies.

In recent years, my interest in the plant Mitragyna speciosa, commonly known as Kratom, has led me to work with an extraordinary diverse group of researchers from around the world ranging from basic sciences to clinical applications. This has led to a number of research collaborations that investigate both the potential benefits of Kratom and its compounds as well as its potential adverse and toxic effects that may require careful monitoring of its use.