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Lab
Science / Animal Research
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1.
Toklu HZ, Yang Z, Oktay S, Sakarya Y, Kirichenko N, Matheny MK, Muller-Delp
J, Strang K, Scarpace
PJ, Wang KKW, Tumer N. Overpressure blast
injury-induced oxidative stress and neuroinflammation response in rat
frontal cortex and cerebellum. Behav Brain Res.
2017 Apr 15. pii: S0166-4328(17)30632-0. doi: 10.1016/j.bbr.2017.04.025
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2.
Toklu HZ, Scarpace PJ, Sakarya Y, Kirichenko N, Matheny M, Bruce EB, Carter CS, Morgan D,
Tumer N. Intracerebroventricular tempol
administration in older rats reduces oxidative stress in the hypothalamus
but does not change STAT3 signalling or
SIRT1/AMPK pathway. Appl Physiol
Nutr Metab. 2017
Jan;42(1):59-67. doi: 10.1139/apnm-2016-0067.
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3.
Toklu HZ, Sakarya Y, Matheny M, Kirichenko
N, Bruce E, Carter CS, Morgan D, Scarpace PJ , Tumer N.
Anorexic response to rapamycin does not appear to involve a central
mechanism. Clin Exp Pharmacol Physiol. 2016 Sep;43(9):802-7
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4.
Ekiz A, Ozdemir-Kumral ZN, Ersahin M,
Tugtepe H, Ogunc AV, Akakin D, Kiran D, Ozsavci D,
Biber N, Hakan T, Yegen B, Sener G, Toklu
HZ. Functional and structural changes of the urinary bladder
following spinal cord injury; treatment with alpha lipoic acid. Neurourol Urodyn. 2017
Apr;36(4):1061-1068
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5.
Tinay I, Sener TE, Cevik O, Cadirci S, Toklu H, Cetinel S, Sener G, Tarcan T.
Antioxidant Agent Quercetin
Prevents Impairment of Bladder Tissue Contractility and Apoptosis in a Rat Model of Ischemia/Reperfusion Injury. Low Urin Tract Symptoms. 2017 May;9(2):117-123. doi: 10.1111/luts.1
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6.
Toklu HZ, Toklu HZ, Muller-Delp J, Sakarya Y, Oktay S, Kirichenko
N, Matheny M, Carter CS, Morgan D, Strehler K, Tumer N, Scarpace PJ. High dietary fructose does not exacerbate the detrimental consequences of high fat diet
on basilar artery function. J Physiol Pharmacol 2016 Apr;67(2):205-16
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7.
Strehler KYE, Matheny
M, Kirichenko N, Sakarya
Y, Bruce E, Toklu HZ, Carter CS, Morgan D, Tumer
N, Scarpace PJ. Onset of Leptin Resistance Shows
Temporal Differences Related to Dose or Pulsed Treatment. Eur J Pharmacol
2016 May 15;779:177-85
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8.
Bruce E, Carter CS, Yasemin S, Matheny MK, Kirichenko N, Toklu
HZ, Morgan D, Tumer N, Scarpace PJ. Rapamycin Reduces
Bodyweight and Improves Leptin Signaling in a Rodent Model of Diet-Induced
Obesity. (revision submitted)
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9.
Yarrow JF, Toklu HZ, Balaez A, Phillips EG, Otzel DM, Chen C, Wronski TJ, Aguirre JI,
Sakarya Y, Tumer N, Scarpace
PJ. Fructose consumption
does not worsen bone deficits resulting from high-fat feeding in young Male rats. Bone. 2016 Feb 5. pii: S8756-3282(16)30027-8. doi:
10.1016/j.bone.2016.02.004.
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10.
Toklu HZ, Muller-Delp
J, Yang Z, Oktay Ş, Sakarya Y, Strang K, Ghosh P, Delp MD, Scarpace PJ, Wang KK, Tumer N. The functional and structural changes in the basilar artery due to overpressure
blast injury. J Cereb Blood Flow Metab. 2015 Dec;35(12):1950-6.
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11.
Kwon OS, Smuder
AJ, Wiggs MP, Hall SE, Sollanek KK, Morton AB, Talbert
EE, Toklu HZ, Tumer N, Powers
SK. AT1 receptor blocker
losartan protects against mechanical ventilation-induced diaphragmatic
dysfunction. J Appl Physiol (1985). 2015 Sep 10:jap.00237.2015.
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12.
Carter CS, Khamiss D,
Matheny M, Toklu HZ, Kirichenko N, Strehler KY, Tumer N, Scarpace PJ, Morgan
D. Rapamycin Versus Intermittent Feeding: Dissociable
Effects on Physiological and Behavioral Outcomes When Initiated Early and
Late in Life. J Gerontol A Biol
Sci Med Sci. 2015 Jan 23. pii: glu238.
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13.
Scarpace PJ, Matheny
M, Strehler KY, Toklu HZ, Kirichenko N, Carter CS, Morgan D, Tumer
N. Rapamycin Normalizes Serum Leptin by
Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats. J Gerontol
A Biol Sci Med Sci. 2015 Jan 23. pii: glu230.
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14. Tumer N, Toklu HZ, Muller-Delp JM, Oktay S, Ghosh
P, Strang K, Delp MD, Scarpace PJ. The effects of aging on the functional and structural properties of
the rat basilar artery. Physiol Rep.
2014 Jun 6;2(6). pii: e12031
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15. Toklu HZ, Kwon OS, Sakarya Y, Powers
SK, Llinas K, Kirichenko
N, Sollanek KJ, Wiggs
MP, Smuder AJ, Talbert EE, Scarpace
PJ, Tumer N. The
effects of enalapril and losartan on mechanical ventilation-induced sympathoadrenal activation and oxidative stress in
rats. J Surg Res.
2014 Feb 6. pii: S0022-4804(14)00093-6.
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16.
Kobeissy F, Mondello S, Tumer N, Toklu
HZ, Whidden MA, Kirichenko
N, Zhang Z, Prima V, Yassin W, Anagli J, Chandra
N, Svetlov S, Wang KK. Assessing neuro-systemic & behavioral components in the
pathophysiology of blast-related brain injury. Front
Neurol. 2013
Nov 21;4:186.
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17.
Sılay
MS, Toklu H, Özağarı A, Aydın M, Tetik Ş, Şener G, Miroğlu C, Kendirci M. Montelukast prevents testes against
ischemia-reperfusion injury through suppression of iNOS
expression. Turk J Urol. 2014 Dec;40(4):221-7. doi:
10.5152/tud.2014.61587.
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18.
Toklu HZ, Kabasakal L, Imeryuz N,
Kan B, Celikel C, Cetinel S, Orun O, Yuksel M, Dulger GA. A study
comparing the efficacy of antimicrobial agents versus enzyme (P-gp) inducers in the treatment of 2,4,6 trinitrobenzenesulfonic acid-induced colitis in rats. J Physiol Pharmacol. 2013 Aug;64(4):439-51.
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19. Ersahin M, Ozsavcı D, Sener A, Ozakpinar OB, Toklu HZ, Akakin D, Sener G, Yegen BC. Obestatin
alleviates subarachnoid haemorrhage-induced oxidative injury in rats via
its anti-apoptotic and antioxidant effects. Brain Inj. 2013;27(10):1181-9
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20. Cevik O, Ersahin M, Sener
TE, Tinay I, Tarcan T, Cetinel S, Sener A, Toklu HZ, Sener
G. Beneficial
effects of quercetin on rat urinary bladder after spinal cord injury. J Surg Res. 2013 Aug;183(2):695-703.
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21. Ersahin M, Toklu
HZ, Erzık C, Akakin
D, Tetık S, Sener
G, Yegen BC. Ghrelin
alleviates spinal cord injury in rats via its anti-inflammatory effects. Turk Neurosurg.
2011;21(4):599-605
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22. Ozsavci D, Ersahin
M, Sener A, Ozakpinar OB,
Toklu
HZ, Akakin D, Sener
G, Yegen BC. The novel function of nesfatin-1
as an anti-inflammatory and antiapoptotic peptide in subarachnoid
hemorrhage-induced oxidative brain damage in rats.
Neurosurgery. 2011 Jun;68(6):1699-708
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23. Hakan T, Toklu
HZ, Biber N, Celik H, Erzik C, Ogunc AV, Cetinel S, Sener G. Meloxicam exerts neuroprotection on spinal cord trauma
in rats. Int J Neurosci.
2011 Mar;121(3):142-8.
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24. Ersahin M, Toklu
HZ, Akakin D, Yuksel
M, Yegen BC, Sener G. The effects of Nigella sativa against oxidative injury
in a rat model of subarachnoid hemorrhage. Acta Neurochir (Wien). 2011; 153(2):333-41.
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25. Toklu HZ, Hakan T, Celik
H, Biber N, Erzik C, Ogunc AV, Akakin D, Cikler E, Cetinel S, Ersahin M, Sener G.
Neuroprotective effects of alpha-lipoic acid in experimental spinal cord
injury in rats. J Spinal Cord Med. 2010;33(4):401-9.
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26.
Toklu HZ, Sehirli
O, Ersahin M, Suleymanoglu
S, Yiginer O, Emekli-Alturfan
E, Yarat A, Yegen BC, Sener G. Resveratrol improves cardiovascular function and
reduces oxidative organ damage in the renal, cardiovascular and cerebral
tissues of two-kidney, one-clip hypertensive rats. J Pharm Pharmacol. 2010; 62(12):1784-93.
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27.
Ersahin M, Toklu HZ, Erzik C, Cetinel S, Akakin D, Velioglu-Ogunc A, Tetik S, Ozdemir ZN, Sener G, Yegen BC. The anti-inflammatory and neuroprotective effects of
ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats. J Neurotrauma. 2010
Jun;27(6):1143-55.
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28. Ersahin M, Toklu HZ, Cetinel S, Yuksel M, Erzik C,
Berkman MZ, Yegen BC, Sener
G. Alpha
Lipoic Acid Alleviates Oxidative Stress and Preserves Blood Brain
Permeability in Rats with Subarachnoid Hemorrhage. Neurochem Res. 2010 Mar;35(3):418-28.
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29. Velioglu-Ogunc A, Sehirli O, Toklu
HZ, Ozyurt H, Mayadagli
A, Eksioglu-Demiralp E, Erzik C, Cetinel S, Yegen BC, Sener G. Resveratrol
protects against irradiation-induced hepatic and ileal
damage via its anti-oxidative activity. Free Radic Res. 2009 Aug 25:1-12.
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30. Hakan T, Toklu HZ, Biber N, Ozevren H, Solakoglu S, Demirturk P, Aker FV. Effect of COX-2
inhibitor-meloxicam against traumatic brain injury induced biochemical,
histopathological changes and blood brain barrier permeability. Neurol Res 2010
Jul;32(6):629-35.
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31.
Ersahin M, Sehirli O, Toklu
HZ, Suleymanoglu S, Emekli-Alturfan E, Yarat A, Tatlidede
E, Yegen BC, Sener G. Melatonin
improves cardiovascular function and ameliorates renal, cardiac and
cerebral damage in rats with renovascular
hypertension. J Pineal Res. 2009; 47(1):97-106
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32.
Biber N, Toklu HZ, Solakoglu S, Gultomruk M, Hakan T, Berkman Z, Dulger G.
Cysteinyl-leukotriene receptor antagonist montelukast decreases blood-brain barrier permeability
but does not prevent edema formation in traumatic brain injury. Brain
Injury 2009, 23:577-84.
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33.
Toklu
HZ, Sehirli O, Ozyurt H, Mayadagli A, Demiralp E, Cetinel S, Sahin H, Yegen B, Ulusoylu Dumlu M, Gokmen V, Sener G. Punica Granatum Peel Extract Protects Against
Ionizing Radiation-Induced Enteritis And Leukocyte
Apoptosis In Rats. J Radiat Res
(Tokyo). 2009;50(4):345-53.
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34. Toklu
HZ, Hakan T, Biber
N, Solakoglu S, Ogunc
AV, Sener G. The protective effect
of alpha lipoic acid against traumatic brain injury in rats. Free Rad Res 2009
Jul;43(7):658-67.
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35. Ersahin M, Toklu HZ, Cetinel S, Yuksel M, Yegen BC, Sener G. Melatonin
reduces experimental subarachnoid hemorrhage-induced oxidative brain damage
and neurological symptoms. J Pineal Res. 2009
Apr;46(3):324-32.
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36.
Karakus
S, Kocyigit -Kaymakcioglu
B, Toklu HZ, Aricioglu F, Rollas S. Synthesis and anticonvulsant
activity of new N-(alkyl/sub-stituted
aryl)-N'-[4-(5-cyclohexylamino)-1,3,4-thiadiazole-2-yl)phenyl]thioureas. Arch Pharm (Weinheim). 2009 Jan;342(1):48-53.
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37.
Toklu HZ,
Keyer Uysal M, Kabasakal L, Sirvanci S, Ercan F, Kaya M. The Effects of Riluzole
on Neurological, Brain Biochemical, and Histological Changes in Early and
Late Term of Sepsis in Rats. J Surg Res. 2009 Apr;152(2):238-48.
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38.
Kocyigit-Kaymakcioglu
B, Toklu HZ, Ikiz S, Bagcigil AF, Rollas S, Ozgur NY, Ak S. Synthesis and
antinociceptive-antimicrobial activities of some new amide derivatives of
3,5-di/-and 1,3,5-trimethylpyrazoles. J Enzyme Inhib
Med Chem. 2008 Aug;23(4):454-61.
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39.
Toklu HZ, Tunali-Akbay T, Velioglu-Ogunc
A, Ercan F, Gedik N, Keyer-Uysal M, Sener G. Silymarin, the antioxidant component of Silybum marianum, prevents
sepsis-induced oxidative injury of lung and brain. J Surgical Research 2008
145(2) 214-222
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40.
Toklu HZ,
Dumlu MU, Sehirli O, Ercan F, Gedik N, Gokmen V, Sener G.
Pomegranate peel extract prevents liver fibrosis in biliary-obstructed
rats. J Pharm Pharmacol. 2007 Sep;59(9):1287-95.
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41.
Sener
G; Sehirli O; Toklu H; Ercan F; Alican I. Montelukast Reduces Ischemia/Reperfusion-Induced
Bladder Dysfunction and Oxidant Damage in the Rat. J Pharmacy Pharmacol 2007, 59:837-842
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42.
Dulundu
E, Ozel Y, Topaloglu U,
Toklu
H, Ercan F, Gedik
N, Sener G Grape Seed Extract Reduces Oxidative
Stress and Fibrosis in Experimental Biliary Obstruction Journal of Gastroenterology
and Hepatology 2007 Jun;22(6):885-92.
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43.
Toklu HZ,
Tunali T, Erkanlı
G, Yuksel M, Ercan F, Sener G. Silymarin, the
antioxidant component of Silybum marianum, protects against burn-induced oxidative skin
injury. Burns 2007 33 (7): 908-916.
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44.
Sener
G, Sehirli AO, Toklu HZ, Yuksel M, Ercan F, Gedik N. Erdosteine treatment
attenuates oxidative stress and fibrosis in experimental biliary
obstruction. Pediatr Surg
Int. 2007 Mar;23(3):233-41.
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45.
Sener G, Toklu HZ, Cetinel S: b-glucan
protects against chronic nicotine-induced oxidative damage in rat kidney
and bladder. Environmental Toxicology Pharmacology 23 (1) 2007, 25-32
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46.
Toklu
HZ, Alican I, Ercan F, Sener G: The beneficial effect of
resveratrol on rat bladder contractility and oxidant damage following
ischemia/reperfusion. Pharmacology. 2006 Aug 21;78(1):44-50
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47.
Toklu
HZ., Sehirli AO, Velioglu-Ogunc A., Cetinel
S., Sener G. Acetaminophen-induced
toxicity is prevented by β-D-glucan treatment in mice. European
Journal Pharmacology Volume 543,
Issues 1-3, 14 August 2006, Pages 133-140
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48.
Sener G., Toklu HZ, Sehirli
AO, Velioglu-Ogunc A, Cetinel
S, Gedik N. Protective Effects of
Resveratrol Against Acetaminophen-Induced Toxicity In
Mice. Hepatology Res. 2006; 35(1):
62-68.
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49.
Toklu HZ, Sener
G, Jahovic N, Uslu B, Arbak
S, Yegen BC. Beta-glucan protects against burn-induced oxidative organ damage in
rats. Int Immunopharmacol.
2006 Feb;6(2):156-69.
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50.
Sener G, Toklu HZ, Erkanli G, Ercan F.
Protective Effect of β-Glucan Against Oxidative Organ Injury in a Rat
Model of Sepsis. Int Immunopharmacol.
2005 Aug;5(9):1387-96.
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51.
Sener G, Toklu
H, Kapucu C, Ercan F, Erkanlı G, Kacmaz A, Tilki M, Yegen BC. Melatonin
Protects Against Oxidative Organ Injury In A Rat
Model Of Sepsis. Surgery Today
2005; 35(1):52-59.
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52.
Sener
G, Paskaloglu K, Toklu H, Kapucu
C, Ayanoglu-Dulger G, Kacmaz
A, Sakarcan A. Melatonin ameliorates chronic
renal failure-induced oxidative organ damage in rats. Journal of Pineal
Research 2004; 36(4): 232-241
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Under maiden name
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53.
Oruc EE,
Kocyigit-Kaymakcioglu B, Oral B, Altunbas-Toklu HZ, Kabasakal L,
Rollas S. Synthesis of some novel azo derivatives
of 3,5-dimethyl-1-(2-hydroxyethyl) pyrazole as
potent analgesic agents. Arch Pharmazie (Weinheim).
2006 May;339(5):267-72.
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54.
Aricioglu
F, Altunbas
H. Harmane
induces anxiolysis and antidepressant-like
effects in rats. Annals of New York Academy of Science 2003; 1009: 196-201
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55.
Aricioglu
F, Altunbas H. Agmatine an
endogenous anxiolytic/ antidepressant agent? Annals of New York Academy of
Science 2003; 1009: 136-140
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56.
Sener
G, Sehirli AO, Altunbas
HZ, Ersoy Y, Paskaloglu
K, Arbak S, Ayanoglu-Dulger
G. Melatonin protects against gentamicin-induced nephrotoxicity in rats.
Journal of Pineal Research 2002; 32(4): 231-236
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Human
Studies/ Pharmacy Practice/ Education
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57. Toklu
HZ. Pharmacovigilance
of Herbal Medicine: Herbavigilance.
Adv. Pharmacoepidemiol. Drug Saf.
2016; 5(4):208
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58. Toklu
HZ, Mensah E. Why
do we need pharmacists in pharmacovigilance systems?
Online Journal of Public Health Informatics 2016; 8(2):e193
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59.
Toklu HZ,
Soyalan M, Gultekin O, Ozpolat
M, Aydin MD, Gunay AC, Akici
A, Ozkum D, Demirdamar
R. The
knowledge and attitude of the health professionals towards
pharmacovigilance and adverse drug reaction reporting in Northern Cyprus.
J Pharmacovigilance 2016; 4: 193.
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60.
Toklu HZ.
Promoting
evidence-based practice in pharmacies. Integrated
Pharmacy Research and Practice 2015;4 127-131
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61.
Toklu HZ.
Pharmaceutical
Education Vs. Pharmacy Practice: Do We Really Teach What They Need For
Practicing? J Pharma Care Health Sys 2015, S3:e001. doi:10.4172/2376-0419.S3-e001
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62.
Toklu HZ.
Rational
use of medicine in pharmacy practice. Turkiye
Klinikleri J Pharmacol
(special topics) 2015; 3(1):74-83
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63.
Toklu HZ, Hussain A. The changing face of pharmacy practice and the need for a new model
of pharmacy education. J Young Pharm.
2013 Jun;5(2):38-40.
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64.
Toklu HZ. Problem based pharmacotherapy teaching for pharmacy students and
pharmacists. Curr
Drug Deliv. 2013 Feb;10(1):67-70.
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65.
Toklu HZ,
Demirdamar R. The evaluation of prescription dispensing
scores of the pharmacy students before and after the problem-based rational
drug use course: Results of the two years
experience. Marmara Pharm J. 2013; 17(3): 175-180.
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66.
Ozkum
D, Akı O, Toklu HZ. Herbal
medicine use among diabetes mellitus patients in Northern Cyprus.
J Med Plant Res. 2013;7(22):1652-64.
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67.
Toklu HZ,
Dulger GA, Hıdıroğlu
S, Akici A, Yetim A, Gannemoğlu HM, Gunes H. Knowledge
and attitudes of the pharmacists, prescribers and patients towards generic
drug use in Istanbul - Turkey. Pharm Pract (Granada). 2012 Oct;10(4):199-206.
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68.
Gokcekus
L, Toklu HZ, Demirdamar
R, Gumusel B. Dispensing practice in the community pharmacies in the Turkish
Republic of Northern Cyprus. Int J Clin Pharm. 2012
Apr;34(2):312-24.
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69. Toklu
HZ, Demirdamar R, Gumusel B, Yaris E, Dulger G. Rational
drug use awareness of the nurses in the Turkish Republic of Northern Cyprus Near East University Hospital. Marmara Pharm J 2012; 16(2): 150-154
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70. Demirdamar
R, Toklu HZ, Gumusel B. Pharmacy
education in Turkish Republic of Northern Cyprus. Educational Research 2012;
3(1):1-6.
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71. Toklu
HZ, Akıcı A, Keyer
Uysal M, Dülger G. The
role of the doctor and pharmacist in improving patient compliance in the process of rational drug use.
Turkısh J Family Practice. 2010; 14(3): 139-145
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72. Toklu
HZ, Akici A, Oktay
S, Cali S, Sezen SF, Keyer-Uysal
M. Pharmacy
practice of community pharmacists in Turkey.
Marmara Pharm J, 2010; 14(1):53-60.
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73.
Toklu
HZ, Keyer-Uysal M. The knowledge and attitude of the Turkish community pharmacists
toward pharmacovigilance in the Kadikoy district
of Istanbul. Pharmacy
World Science 2008 Oct;30(5):556-62.
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74.
Akıcı A,
Kalaca S, Ugurlu U, Toklu
HZ, Oktay S. Antihypertensive
drug utilization at health centers in a district of Istanbul.
Pharmacy World & Science 2007
Jun;29(3):116-21.
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75.
Akıcı
A, Kalaca S, Ugurlu MU,
Toklu
HZ, Iskender E, Oktay S. Patient knowledge
about drugs prescribed at primary healthcare facilities.
Pharmacoepidemiology and Drug Safety 2004 Dec; 13(12): 871-876.
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Dr. Hale Z. TOKLU 
