Michael Andrew Bewernitz, Ph.D.

J. Crayton Pruitt Family Department of Biomedical Engineering

The University of Florida, Gainesville, Florida

 

 

Education

 

       April 2008
Ph.D. in biomedical engineering from the J. Crayton Pruitt Family Department of Biomedical Engineering,
University of Florida. Thesis title: “Data Mining and Time Series Analysis of Brain Dynamical Behavior with Applications in Epilepsy”

 

       August 2007

M.E. in biomedical engineering from the J. Crayton Pruitt Family Department of Biomedical Engineering,
University of Florida

 

       May 2002
B.S. in chemical engineering from the Department of Chemical Engineering, Michigan State University
*
Biochemical engineering specialization* (chemical engineering specialization option)

 

Research Interests

 

       Pharamcological and neurostimulation dose-response research for optimization of therapeutic control strategies

       Generalized absence epilepsy spike and wave detection and stratification using electroencephalogram (EEG) data

       Nuclear magnetic resonance image (NMRI) analysis in brain and spinal cord injury research

 

I am studying the application of time series analysis and machine learning techniques to biomedical time-series datasets.  My current research focuses on characterization of therapeutic effects using electroencephalographic recordings obtained from patients or animal models of neurological disorders.  The goal of this research is to improve the understanding of therapeutic mechanisms and develop enhanced physiologic model-based treatment approaches.

 

Conference Talks

 

Michael Bewernitz, Onur Seref, Basim Uthman, Panos Pardalos. A Novel Generalized Spike-Wave Detector: Towards Real-Time Applications in Epilepsy. Conference on Computational Neuroscience 2008. Feb 21st, 2008. University of Florida, Gainesville, Florida.

 

Michael Bewernitz, George Ghacibeh, Onur Seref, Basim Uthman, Panos Pardalos. Support Vector Machine Classification of EEG Data From Epileptic Patients Treated with Vagus Nerve Stimulation. Data Mining, Systems Analysis and Optimization in Biomedicine. March 28th, 2007. University of Florida, Gainesville, Florida.

 

Michael Bewernitz, Jabriel Riley, Zhao Liu, Paul Carney, Lewis Baxter, J. Chris Sackellares. A Novel In-Vivo Seizure Model of Frontal Basal Forebrain Origin in an Anolis Lizard. DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience. February 15th, 2006. University of Florida, Gainesville, Florida.

 

Publications

 

Bewernitz M.A., Ghacibeh G., Seref O., Pardalos P.M., Liu C.C., Uthman B. Quantification of the impact of vagus nerve stimulation parameters on electroencephalographic measures. Proceedings of the conference on Data Mining, Systems Analysis and Optimization in Biomedicine. Gainesville, (FL), 28-30 March 2007, AIP Conference Proceedings, No. 953, pp. 206-219.

 

Busygin S., Boyko N., Pardalos P.M., Bewernitz M.A., Ghacibeh G. Biclustering EEG data from epileptic patients treated with vagus nerve stimulation. Proceedings of the conference on Data Mining, Systems Analysis and Optimization in Biomedicine. Gainesville, (FL), 28-30 March 2007, AIP Conference Proceedings, No. 953, pp. 220-231.

 

Uthman B., Bewernitz M.A., Liu C.C., Ghacibeh G. Optimization of epilepsy treatment with vagus nerve stimulation. Proceedings of the conference on Data Mining, Systems Analysis and Optimization in Biomedicine. Gainesville, (FL), 28-30 March 2007, AIP Conference Proceedings, No. 953, pp. 308-315.

 

Nair SP, Bewernitz M. A., Jukkola P. I., Shiau D.S., Sackellares J. C., Kelly K. M.. EEG Responses to Intracerebroventricular Injections of Midazolam in Rats. AES 61st Annual Meeting 2007, Nov. 30 - Dec. 4, Philadelphia, PA (in print).

 

Seref O., Kundakcioglu O.E., Bewernitz M.A.Support vector machines in neuroscience”, Encyclopedia of Healthcare Information Systems, N. Wickramasinghe and E. Geisler (editors), IDEA Group Inc., 2007, accepted for publication.

 

Carney P.R., Shiau D.S., Iasemidis L.D., Suharitdamrong W., Shenk D., Bewernitz M.A., Nair S.P., Pardalos P.M., Sackellares J.C. Nonlinear quantitative EEG analysis distinguishes normal from seizure-prone newborns. AES 58th Annual Meeting 2004, Dec. 3 - 7, New Orleans, LA. Epilepsia 45 (S7): 269-270, 2004.

 

Patents

 

Basim Uthman, Panos Pardalos, Michael Bewernitz, Chang-Chia Liu, Stanislav Busygin. Variational Parameter Neurostimulation Paradigm for Treatment of Neurologic Disease. U.S. Provisional Application Serial No. 60/908,591.

 

Marketing communication from the University of Florida Office of Technology and Licensing:

http://apps.rgp.ufl.edu/otl/pdf/marketing/12501.pdf

 

News article regarding the patent, published in Medical Device & Diagnostic Industry, © 2008:
http://www.devicelink.com/mddi/archive/08/04/011.html

 

Research Protocols

 

Sub-Investigator

Quantitative Electroencephalographic and Evoked Potential Changes Resulting from Brivaracetam Treatment are Associated with Reduction of Myoclonus in Patients with Unverricht Lundborg Disease. (IRB #489-2007)

 

Sub-Investigator

Examining the Effect of Lamotrigine for Newly Diagnosed Absence Seizures using Quantitative EEG Analysis. (IRB # 559-2007)

 

Sub-Investigator

Differentiating Status Epilepticus from other Encephalopathies using Quantitative EEG Analysis. (IRB # 252-2007)

 

Conference Organization Committee

 

Conference on Computational Neuroscience 2008. February 20-21, 2008. University of Florida, Gainesville. 

 

Data Mining, System Analysis and Optimization in Biomedicine. March 28-30, 2007. University of Florida, Gainesville.

 

Ad Hoc Reviewer

 

BIOMAT 2007: International Symposium on Mathematical and Computational Biology. Armação dos Búzios, Rio de Janeiro, RJ, 24th – 29th November. www.biomat.org 

 

Journal of Combinatorial Optimization

 

Awards and Honors

 

       Physics Instructor, Science: Optimizing Academic Returns (SOAR) Project,  Science Content Enrichment Series (High School), funding provided by the Panhandle Area Education Consortium (PAEC), Tallahassee Florida, June 16-19, 2008

 

       Teaching assistantship, Howard-Hughes Medical Institute (HHMI) Science For Life program, University of Florida, Fall 2007-Spring 2008

 

       Award,  Impact Award for community service, presented by The Dean of Students Office and the Center for Leadership & Service at the University of Florida, March 27, 2007

 

       Honorable mention, selected to represent Michigan State University in the American Institute of Chemical Engineering (AICHE) National Student Design Competition, Spring, 2002

 

       GPA, earned 3.9/4.0 GPA in UF Biomedical Engineering

 

Contact Information

 

       Email:

 

 

       Phone:
(352) 392-1464, x:2050

       Office location

Center for Applied Optimization
401 Weil Hall
University of Florida
Gainesville, FL-32610

 

       Mailing address
130 BME Building
P.O. Box 116131
Gainesville, FL 32611-6131
USA

 

 

Last updated 4-12-08